Description
Tablets are yellow, square, flat on both sides and chamfered, engraved "BP" on one side and "50" on the other, with rounded edges. Marbling is allowed on the surface of the tablets. Dosage form Tablets. PHARMACOTHERAPEUTIC GROUP and ATC code Steroid anabolic, A14A A05. PHARMACOLOGICAL PROPERTIES: Oxymetholone is an anabolic steroid. Penetrating into the cell nucleus, it activates the genetic apparatus of the cell, which leads to an increase in the synthesis of DNA, RNA and structural proteins, the activation of tissue respiration chain enzymes and an increase in tissue respiration, oxidative phosphorylation, ATP synthesis and the accumulation of macroergs inside the cell. Stimulates anabolic and suppresses catabolic processes caused by glucocorticoids. It leads to an increase in muscle mass, a decrease in fat deposits, improves tissue trophism, promotes the deposition of calcium in the bones, retains sodium and water in the body. Hematopoietic action is associated with an increase in the synthesis of erythropoietin. Androgenic activity (low) can contribute to the development of male secondary sexual characteristics. INDICATIONS: Protein synthesis disorders, cachexia of various origins, injuries, extensive burns, after infectious diseases and radiation, muscular dystrophy, osteoporosis, negative nitrogen balance during corticosteroid therapy, hypo- and aplastic anemia. METHOD OF APPLICATION AND DOSES: Adults are prescribed at a dose of 2-3 mg/kg. The duration of treatment is 3 months and can be extended depending on the result. SIDE EFFECTS: In women – virilization symptoms, ovarian depression, menstrual disorders, hypercalcemia. In men: in the prepubertal period – symptoms of virilization, idiopathic hyperpigmentation of the skin, slowdown or cessation of growth (calcification of the epiphyseal growth zones of tubular bones), in the postpubertal period – bladder irritation, gynecomastia, priapism, in old age – hypertrophy and / or carcinoma of the prostate gland . In men and women – the progression of atherosclerosis, peripheral edema, dyspeptic disorders, impaired liver function with jaundice, changes in the leukocyte formula, pain in long bones, hypocoagulation with a tendency to bleeding. CONTRAINDICATIONS Hypersensitivity to the drug, prostate cancer, breast cancer in men, breast carcinoma in women with hypercalcemia, ischemic heart disease, severe atherosclerosis, nephritis, nephrotic syndrome, liver and kidney failure, acute and chronic prostatitis, pregnancy, breastfeeding. OVERDOSAGE: No cases of overdose have been reported. PRECAUTIONS AND PECULIARITIES OF APPLICATION: When the first signs of virilization appear in women (coarsening of the voice, hirsutism, acne, clitoromegaly), the intake should be stopped to prevent irreversible changes. Suppression of coagulation factors II, VII, VII and X and an increase in prothrombin time may occur. Periodically check the level of lipidemia and cholesterolemia. For children, the drug should be prescribed by an experienced specialist in order to prevent premature ossification of the epiphyses of the bones. INTERACTION WITH OTHER DRUGS: Glucocorticoids, mineralocorticoids, corticotropin, sodium-containing drugs and sodium-rich foods potentiate fluid retention in the body, increase the risk of edema, and increase the severity of acne.Enhances the effects of antiplatelet agents, indirect anticoagulants, insulin and oral antidiabetic agents weakens – somatotropin and its derivatives. NAME AND ADDRESS of manufacturer: SC Balkan Pharmaceuticals SRL
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