Description
DESCRIPTION OF THE PREPARATION: Transparent oily solution, from light yellow to yellow, with a characteristic odor. release form Solution for injection oily. PHARMACOTHERAPEUTIC GROUP and ATC code: Steroid anabolic, A14A B01. PHARMACOLOGICAL PROPERTIES: Nandrolone phenylpropionate has a shorter half-life (2-4 days) than nandrolone decanoate or Deca (7-10 days). That is why nandrolone phenylpropionate acts shorter than Deca. According to experienced athletes, this drug causes much less water retention, and for this reason it is more compatible with "androgens" than nandrolone decanoate. The ether chain of Phenylpropionate is approximately 2 times shorter than that of decanoate, due to which the active substance is absorbed into the blood faster and has a shorter exposure time to the body. Therefore, phenylpropionate has its advantages: 1 – a shorter period of action significantly reduces the frequency of side effects of nandrolone. 2 – the recovery time of endogenous testosterone after the course is reduced. 3 – if side effects or poor tolerance occur, the course can be stopped and all unwanted reactions will quickly disappear. The only drawback of phenylpropionate is the need for frequent injections, but this is not essential. pharmacokinetic properties. After the / m administration of 100 mg Cmax is created in 1-3 weeks. Undergoes biotransformation in the liver with the formation of 17-ketosteroids. It is excreted mainly with urine (over 90%) and about 6% with faeces.INDICATIONS: Treatment of anemia in renal failure (increases hemoglobin content and cell mass), diabetic retinopathy, myodystrophy, Werding-Hoffmann spinal amyotrophy, breast cancer (adjuvant), glomerulonephritis, extensive burns, osteoporosis. METHOD OF APPLICATION AND DOSES: V / m, deeply. with anemia (simultaneously with iron preparations) – 100-200 mg (for women – 50-100 mg) 1 time per week, to stimulate anabolic processes – 50-200 mg (for women – 50-100 mg) 1 time in 1-4 weeks , children 2-13 years old – 0.4 mg / kg 1 time in 3-4 weeks. Duration of the course (with a 1-4-week interval between injections) – up to 12 weeks, a second course – 8 weeks after the last injection of the drug. Treatment is carried out against the background of a diet rich in proteins. SIDE EFFECTS: In women, virilization symptoms, ovarian depression, menstrual disorders, hypercalcemia. In men: in the prepubertal period – symptoms of virilization, idiopathic hyperpigmentation of the skin, slowing or cessation of growth (calcification of the epiphyseal growth zones of tubular bones), in the postpubertal period – bladder irritation, gynecomastia, priapism, in old age – hypertrophy and / or carcinoma of the prostate gland . In men and women – the progression of atherosclerosis, peripheral edema, dyspeptic disorders, impaired liver function with jaundice, changes in the leukocyte formula, pain in long bones, hypocoagulation with a tendency to bleeding. CONTRAINDICATIONS: Hypersensitivity to the drug, prostate cancer, breast cancer in men, breast carcinoma in women with hypercalcemia, ischemic heart disease, severe atherosclerosis, nephrotic syndrome, acute and chronic liver diseases, incl.alcoholic lesions, nephritis, pregnancy, breastfeeding. OVERDOSAGE: No cases of overdose have been reported. PRECAUTIONS AND PECULIARITIES OF APPLICATION: When the first signs of virilization appear in women (coarsening of the voice, hirsutism, acne, clitoromegaly), the intake should be stopped to prevent irreversible changes. Suppression of coagulation factors II, VII, IX and X and an increase in prothrombin time may occur. Periodically check the level of lipidemia and cholesterolemia. For children, the drug should be prescribed by an experienced specialist in order to prevent premature ossification of the epiphyses of the bones. INTERACTION WITH OTHER DRUGS: Glucocorticoids, mineralocorticoids, corticotropin, sodium-containing drugs and sodium-rich foods potentiate fluid retention in the body, increase the risk of edema, and increase the severity of acne. Enhances the effects of antiplatelet agents, indirect anticoagulants, insulin and oral antidiabetic agents weakens – growth hormone and its derivatives. STORAGE CONDITIONS: Store at a temperature of 15-25°C, in a dry, dark place and out of the reach of children. EXPIRY DATE: 5 years. Do not use after the expiry date stated on the package. NAME AND ADDRESS of the manufacturer: SC Balkan Pharmaceuticals SRL st. Gradescu, 4 Chisinau, Republic of Moldova
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